![]() Galimberti V, Cole BF, Viale G, Veronesi P, Vicini E, Intra M, et al. A randomized clinical trial on sentinel lymph node biopsy versus axillary lymph node dissection in breast cancer: results of the Sentinella/GIVOM trial. Zavagno G, De Salvo GL, Scalco G, Bozza F, Barutta L, Del Bianco P, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. Mansel RE, Fallowfield L, Kissin M, Goyal A, Newcombe RG, Dixon JM, et al. Sentinel node biopsy compared with complete axillary dissection for staging early breast cancer with clinically negative lymph nodes: results of randomized trial. Therefore, intraoperative FSE for SLN should not be routinely performed for all breast cancer patients.īreast neoplasms False negative reactions Frozen sections Sentinel lymph node biopsy.Ĭanavese G, Catturich A, Vecchio C, Tomei D, Gipponi M, Villa G, et al. However, the false-negative results of FSE for SLNs based on the size of the metastatic node did not change our practice. Some patients may show transition in their permanent pathology due to the size of the metastatic node. Most patients were not indicated for axillary lymph node dissection. ![]() Several clinicopathological factors, including the size of SLN metastases, suspicious preoperative axillary lymph nodes, and luminal B subtype, were associated with a higher rate of false-negative results. The sensitivity and false-negative rate of FSE were 86.4% and 13.6%, respectively. Among metastatic SLNs, micrometastasis was found in 234 (16.8%). Seventy-one patients (1.7%) had confirmed pathologic N2 or N3 stage. We evaluated factors associated with the false-negative results of FSE for SLNs using the Generalized Estimating Equations model.Ī total of 1,397 SLNs from 908 patients were confirmed to be metastatic. We reviewed the records of 4,219 patients who underwent SLNB for primary invasive breast cancer between 20 at the Severance Hospital. This study aimed to verify the accuracy of FSE for SLNs. ![]() Based on the results of frozen section examination (FSE), surgeons can decide to continue further axillary dissections. Sentinel lymph node (SLN) biopsy (SLNB) is widely performed for axillary staging in patients with breast cancer. ![]()
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